Genoa, Naples, Messina, Valletta, Barcelona

Genoa is a port city in the Northwest of Italy. Home to the Genoa Aquarium, famous for having the largest exposition of biodiversity in Europe, the city is also a great place to visit for anyone interested in architecture.

Naples, in the Campania region, is Italy's third largest city. Its claim to fame is the spectacular location along one of the world's most splendid bays, backed by the perfect cone of Mount Vesuvius. In addition to its beautiful setting, Naples' surprises with other outstanding attractions such as the Royal Palace, San Carlos Opera House, the impressive National Archaeological Museum and the Castel Nuovo, dating from the 13th-century. The city's central area is best explored on foot. Chaotic traffic conditions make driving around the city a very frustrating experience. Naples provides a convenient starting point for trips to such favored destinations as Pompeii, Herculaneum and Mount Vesuvius. The Isle of Capri can be reached via a 45-minute hydrofoil service. The region of Campania was home to Greeks settlers some 300 years before Rome was founded. Pompeii, too, was a Greek town before being conquered by the Romans during the 5th century BC. It was under the Romans that Pompeii flourished and grew prosperous. When Mount Vesuvius erupted in 79 AD, the population of 20,000 was wiped out, but dozens of buildings were preserved under layers of cinder more than 20 feet deep. The most important finds from Pompeii are displayed in Naples' National Archaeological Museum. A visit here will no doubt enhance a visit to ancient Pompeii.

Once the capital of Sicily's ancient kingdom, Messina is a testimony of unified civilizations from across the ages. Invaded by just about every power-hungry nation from the annals of history, the Arab, Greek, Byzantine, and Roman influences remain installed throughout the city's DNA.

However, despite the celebrated heritage, Messina has been installed with contemporary panache and a modern feel. Largely reconstructed under carefully applied security regulations following a series of earthquakes and wartime bombardments, Messina proves that cultural inheritance and present-day necessity can successfully go hand-in-hand.

Home to the Museo Regionale of Messina, known for featuring two of famed artist Michelangelo Merisi da Caravaggio's paintings, and a stunning Cathedral, the city has more to offer than meets the eye. You won't be disappointed.

Malta: the country that God built. Well, kind of. Malta is well-known for being the once-stronghold of the famous religious military order, The Knights Hospitaller, who were granted the land in 1530 from the King of Spain in exchange for an annual fee of one Maltese falcon (which eventually inspired the name of Dashiell Hammett’s famous novel). And these marauding knights certainly did a great job putting the place together. Valletta, the nation’s capital, remains the highlight and exploring this fascinating walled city (which kept the Hospitallers secure until they came across Napoleon in 1798) is akin to walking back in time. It’s small size (just 0.3 square miles) makes it the perfect cruise stopover and is the ideal base for exploring the rest of the country on excursions.

The infinite variety of street life, the nooks and crannies of the medieval Barri Gòtic, the ceramic tile and stained glass of Art Nouveau facades, the art and music, the throb of street life, the food (ah, the food!)—one way or another, Barcelona will find a way to get your full attention. The capital of Catalonia is a banquet for the senses, with its beguiling mix of ancient and modern architecture, tempting cafés and markets, and sun-drenched Mediterranean beaches. A stroll along La Rambla and through waterfront Barceloneta, as well as a tour of Gaudí's majestic Sagrada Famíliaand his other unique creations, are part of a visit to Spain's second-largest city. Modern art museums and chic shops call for attention, too. Barcelona's vibe stays lively well into the night, when you can linger over regional wine and cuisine at buzzing tapas bars.