10-Night London to Bilbao

London is an ancient city whose history greets you at every turn. If the city contained only its famous landmarks—the Tower of London or Big Ben—it would still rank as one of the world's top cities. But London is so much more. The foundations of London's character and tradition endure. The British bobby is alive and well. The tall, red, double-decker buses (in an updated model) still lumber from stop to stop. Then there's that greatest living link with the past—the Royal Family with all its attendant pageantry. To ice the cake, swinging-again London is today one of the coolest cities on the planet. The city's art, style, and fashion make headlines around the world, and London's chefs have become superstars.

Honfleur, the most picturesque of the Côte Fleurie's seaside towns, is a time-burnished place with a surplus of half-timber houses and cobbled streets that are lined with a stunning selection of stylish boutiques. Much of its Renaissance architecture remains intact—especially around the 17th-century Vieux Bassin harbor, where the water is fronted on one side by two-story stone houses with low, sloping roofs and on the other by tall slate-topped houses with wooden facades. Maritime expeditions (including some of the first voyages to Canada) departed from here; later, Impressionists were inspired to capture it on canvas. But the town as a whole has become increasingly crowded since the Pont de Normandie opened in 1995. Providing a direct link with Upper Normandy, the world's sixth-largest cable-stayed bridge is supported by two concrete pylons taller than the Eiffel Tower and designed to resist winds of 257 kph (160 mph).

Cobblestone streets, blooming floral displays, and tiny churches welcome you to this wonderfully pretty harbour. The town of St Peter Port is as pretty as they come, with glowing flower displays painting practically every street corner and window-ledge with colour. As the capital, and main port of Guernsey, St Peter Port puts all of the island’s gorgeous beaches, wonderful history and inspiring stories at your fingertips. Feel the gut punch of the midday gun firing at Castle Cornet, which stands guard over one of the world's prettiest ports. This 800-year-old, Medieval castle offers staggering views of the harbour from its imposing, craggy island location, and you can look out across to the looming shorelines of the other Channel Islands from its weathered battlements. With four well-tended gardens, and five museums offering a rich overview of Guernsey's history, you’ll want to leave a few hours aside to explore the many treasures that lie within the castle’s walls.

Thrust out into the sea and bound to the mainland only by tenuous man-made causeways, romantic St-Malo has built a reputation as a breeding ground for phenomenal sailors. Many were fishermen, but others—most notably Jacques Cartier, who claimed Canada for Francis I in 1534—were New World explorers. Still others were corsairs, "sea dogs" paid by the French crown to harass the Limeys across the Channel: legendary ones like Robert Surcouf and Duguay-Trouin helped make St-Malo rich through their pillaging, in the process earning it the nickname "the pirates' city." The St-Malo you see today isn’t quite the one they called home because a weeklong fire in 1944, kindled by retreating Nazis, wiped out nearly all of the old buildings. Restoration work was more painstaking than brilliant, but the narrow streets and granite houses of the Vieille Ville were satisfactorily recreated, enabling St-Malo to regain its role as a busy fishing port, seaside resort, and tourist destination. The ramparts that help define this city figuratively and literally are authentic, and the flames also spared houses along Rue de Pelicot in the Vieille Ville. Battalions of tourists invade this quaint part of town in summer, so arrive off-season if you want to avoid crowds.

Bordeaux as a whole, rather than any particular points within it, is what you'll want to visit in order to understand why Victor Hugo described it as Versailles plus Antwerp, and why the painter Francisco de Goya, when exiled from his native Spain, chose it as his last home (he died here in 1828). The capital of southwest France and the region's largest city, Bordeaux remains synonymous with the wine trade: wine shippers have long maintained their headquarters along the banks of the Garonne, while buyers from around the world arrive for the huge biennial Vinexpo show (held in odd-number years).Bordeaux is, admittedly, a less exuberant city than many others in France, but lively and stylish elements are making a dent in its conservative veneer. The cleaned-up riverfront is said by some, after a bottle or two, to exude an elegance reminiscent of St. Petersburg, and that aura of 18th-century élan also permeates the historic downtown sector—“le vieux Bordeaux"—where fine shops invite exploration. To the south of the city center are old docklands undergoing renewal—one train station has now been transformed into a big multiplex movie theater—but the area is still a bit shady. To get a feel for the historic port of Bordeaux, take the 90-minute boat trip that leaves Quai Louis-XVIII every weekday afternoon, or the regular passenger ferry that plies the Garonne between Quai Richelieu and the Pont d'Aquitaine in summer. A nice time to stroll around the city center is the first Sunday of the month, when it's pedestrian-only and vehicles are banned.

Time in Bilbao (Bilbo, in Euskera) may be recorded as BG or AG (Before Guggenheim or After Guggenheim). Never has a single monument of art and architecture so radically changed a city. Frank Gehry's stunning museum, Norman Foster's sleek subway system, the Santiago Calatrava glass footbridge and airport, the leafy César Pelli Abandoibarra park and commercial complex next to the Guggenheim, and the Philippe Starck AlhóndigaBilbao cultural center have contributed to an unprecedented cultural revolution in what was once the industry capital of the Basque Country.Greater Bilbao contains almost 1 million inhabitants, nearly half the total population of the Basque Country. Founded in 1300 by Vizcayan noble Diego López de Haro, Bilbao became an industrial center in the mid-19th century, largely because of the abundance of minerals in the surrounding hills. An affluent industrial class grew up here, as did the working class in suburbs that line the Margen Izquierda (Left Bank) of the Nervión estuary.Bilbao's new attractions get more press, but the city's old treasures still quietly line the banks of the rust-color Nervión River. The Casco Viejo (Old Quarter)—also known as Siete Calles (Seven Streets)—is a charming jumble of shops, bars, and restaurants on the river's Right Bank, near the Puente del Arenal bridge. This elegant proto-Bilbao nucleus was carefully restored after devastating floods in 1983. Throughout the Casco Viejo are ancient mansions emblazoned with family coats of arms, wooden doors, and fine ironwork balconies. The most interesting square is the 64-arch Plaza Nueva, where an outdoor market is pitched every Sunday morning.Walking the banks of the Nervión is a satisfying jaunt. After all, this was how—while out on a morning jog—Guggenheim director Thomas Krens first discovered the perfect spot for his project, nearly opposite the right bank's Deusto University. From the Palacio de Euskalduna upstream to the colossal Mercado de la Ribera, parks and green zones line the river. César Pelli's Abandoibarra project fills in the half mile between the Guggenheim and the Euskalduna bridge with a series of parks, the Deusto University library, the Meliá Bilbao Hotel, and a major shopping center.On the left bank, the wide, late-19th-century boulevards of the Ensanche neighborhood, such as Gran Vía (the main shopping artery) and Alameda de Mazarredo, are the city's more formal face. Bilbao's cultural institutions include, along with the Guggenheim, a major museum of fine arts (the Museo de Bellas Artes) and an opera society (Asociación Bilbaína de Amigos de la Ópera, or ABAO) with 7,000 members from Spain and southern France. In addition, epicureans have long ranked Bilbao's culinary offerings among the best in Spain. Don't miss a chance to ride the trolley line, the Euskotram, for a trip along the river from Atxuri Station to Basurto's San Mamés soccer stadium, reverently dubbed "la Catedral del Fútbol" (the Cathedral of Football).